For referrals to substance use and mental health treatment programs, call the Substance Abuse and Mental Health Administration (SAMHSA) National Helpline at 1-800-662-HELP (4357) or visit to find a qualified healthcare provider in your area.988 connects you with a trained crisis counselor who can help. Are you or someone you know experiencing a substance use and/or mental health crisis or any other kind of emotional distress? Please call or text 988 or chat to reach the 988 Suicide & Crisis Lifeline.Poison control can be reached at 1-80 or Please seek immediate medical attention by calling 9-1-1 or visiting an Emergency Department. Are you or someone you know experiencing severe symptoms or in immediate danger?.NIDA supports and conducts research to better understand how illicitly manufactured synthetic cannabinoids impact individual and public health, how to prevent and address related harms, and whether certain synthetic cannabinoids can be used in clinical settings to treat substance use disorders and other health.These products are sometimes known as “K2” and “Spice.” People have reported using these products because they were sometimes cheaper and more accessible alternatives to cannabis and are mostly undetected by routine urine drug screens. Illicitly manufactured synthetic cannabinoids are typically added to liquid cartridges used in vaping devices or added to dried, shredded plant material so they can be smoked. Research shows use of illicit synthetic cannabinoids is associated with severe health problems and can be life-threatening.Some synthetic cannabinoids have potential or current medical uses but many are illicitly manufactured and sold. ![]() Synthetic cannabinoids refer to a class of lab-made substances that are chemically similar to chemicals found in the cannabis plant, though they often produce very different effects.
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